- Reduces muscle soreness after exercise (DOMS)
- Catabolic states, such as major trauma, sepsis, major surgery and bone marrow transplantation as well as intense chemotherapy and radiotherapy, are associated with low plasma levels of glutamine
- Reduced availability of glutamine in these conditions may lead to an impaired immune function because of a reduced capacity of immune cells to proliferate
- Glutamine is the respiratory fuel for the lymphocytes, hepatocytes and the mucosal cells of the gut
- Glutamine is one of the most important substrates for ammoniagenesis, not only in the gut, but also in the kidney, because of its important role in the regulation of acid-base homeostasis
Classified as one of the most abundant amino acids in the body and while technically non-essential as the body can synthesize this amino, it has been shown to be depleted easily when the body is under large amounts of stress such as strenuous exercise and as such is an essential to have if you are training extensively as it helps with DOM’s to regulation of Acid-base homeostasis in the body. Glutamine is also excellent for maintaining mucosal integrity of the gut and immune response mechanisms. Our glutamine is also GMO free and vegan.
L-Glutamine is non-essential and conditionally essential in humans, meaning the body can usually synthesize sufficient amounts of it, but in some instances of stress (such as intense exercise), the body’s demand for glutamine increases and glutamine must be obtained from the diet. In fact, glutamine is so important to the body, it is the most abundant amino acid found in the blood.
A variety of investigations have provided evidence that glutamine has become an important and, possibly essential, amino acid during stressors such as intense exercise. This switch to becoming an essential amino acid appears when the demand of the body for glutamine increases markedly. The plasma glutamine use exceeds the glutamine synthesis of the skeletal muscle and the liver in catabolic conditions. Circulating glutamine is an important substrate for the enterocyte, hepatocyte and immune cells as an oxidative fuel as well as a substrate for nucleotide synthesis.
Muscle medicine: Clinical trials provide important confirmation that dietary glutamine supplementation is indeed associated with amelioration of metabolic response to stress and injury. Moreover, in selected critically ill patients, glutamine seems to improve their outcome. The mechanisms of these effects remain elusive and are the subject of ongoing investigations. Supplemental glutamine improves nitrogen balance and preserves the concentration of glutamine in skeletal muscle.
Fluid balance: In selected patients, glutamine preserves normal distribution of body water by preventing expansion of extracellular water and reducing fluid retention. This is vital for competition prep if you are a body builder or, if you simply want to look better.
Gut health: In the critically ill patient with breakdown of the intestinal barrier, exogenous glutamine may protect the host from gut-derived endotoxemic complications. A possible mechanism for the helpful effects of glutamine on the stressed gut is the increased production of arginine, which serves as a precursor for nitric oxide, a potent vasodilator.
Exercise induced gut leaking: Intestinal permeability and systemic inflammation are associated with gastrointestinal (GI) distress, in which paracellular endotoxin leakage triggers an immune response, causing disruption to intestinal epithelial cell absorption mechanisms. Exercise-induced hyperthermia in humans is associated with an increase in intestinal permeability, commonly called leaky gut, which provokes an inflammatory cascade. This pathway may be responsible for exercise-induced GI distress in which tight junction (TJ) breakdown and increased permeability is the initial phase of the pathway. The good news is that 7 days of oral glutamine supplementation protected the gut during high-intensity endurance exercise by reducing intestinal permeability. Keep in mind, this study induced gut leakage by exercising for a mere 60 minutes. That is an average workout length!
HOW TO TAKE?
- L-Glutamine is best used before or directly after training
- A dose of 5g is standard
- For maximum benefits, expert nutritionists recommended consuming 5g, 1 - 3 times daily, once in the morning, pre and post workout and before bed
- L-Glutamine is esily mixed with water, juice and other supplements